Brainlink-X Lab Day
Dr. Young-Woon Byeon presented at the Brainlink-X Lab Day on electron-beam-based fabrication through 3D reconstruction of solid-state nanopores.
AEML joined the Brainlink-X Lab Day, a gathering of research groups from around the world working in this field to share progress and discuss future directions. AEML participates in the Advanced Nanopore-Nanogap Sensor Platform for Single-Molecule Omics Profiling project.
Dr. Young-Woon Byeon presented “From Fabrication to 3D Reconstruction: Exploring Solid-State Nanopores at KIST”, introducing the 3D imaging of 2D nanopores — the subtopic within the project AEML is participating in.
The talk covered:
- A precise fabrication technique for ultrathin SiN-based nanopores, together with electron-beam structural analyses that elucidate surface tension and shrinkage phenomena.
- Ongoing work on the structure–dynamics correlation of nanopores under various experimental environments, including TEM tilt-series acquisition.
- A roadmap toward applying advanced 3D reconstruction algorithms — Backprojection, SIRT, DART, and Compressed Sensing — for full three-dimensional visualization of nanopore structures.
- Current focus on building quantitative models linking electron-beam conditions to real-time structural evolution, and extending the workflow toward high-fidelity 3D reconstruction.
- Future integration of novel material systems, AI-assisted analytical automation, and nanopore-based sensing applications, leveraging KIST’s analytical infrastructure and interdisciplinary expertise.
Keywords: Solid-State Nanopore · Transmission Electron Microscopy (TEM) · Electron Beam Analysis · AI-Driven Structural Modeling